Statins go beyond cardioprotection

PrO : Statins in the Critically Ill – Go , Statins , Go !

It’s time to consider a change. I propose to you that our name no longer serves our purpose or mission. The ICUs are not what they were 24 years ago when this Society was formed, and essentially everything about how we live and how we provide care has changed dramatically. Our Society has been changing, too, and thus it is time to consider a name change as an opportunity to better position ours...

Benefits of statins beyond lipid lowering

Increasing evidence has accumulated suggesting that inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, or statins, have therapeutic ‘pleiotropic’ effects independent of cholesterol lowering. These include anti-inflammatory and antioxidative properties, improvement of endothelial function and increased nitric oxide bioavailability. In addition to elucidating underlying mech...

New Drugs for Treating Dyslipidemia: Beyond Statins

Statins have been shown to be very effective and safe in numerous randomized clinical trials, and became the implacable first-line treatment against atherogenic dyslipidemia. However, even with optimal statin treatment, 60% to 80% of residual cardiovascular risk still exists. The patients with familial hypercholesterolemia which results in extremely high level of low density lipoprotein cholest...

Statins: Are There Benefits Beyond Cholesterol Lowering

The 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors, or statins, are potent inhibitors of cholesterol synthesis and large clinical trials have demonstrated that these agents reduce cholesterol and the incidence of cardiovascular diseases. Recent evidence, however, suggests that the beneficial effects of statins may extend beyond their effects on serum cholesterol levels. Because stati...

Beyond X 2.0: Where Should We Go?